Key result
Exercise augments autonomic control by increasing PVN nNOS expression and local NO generation, facilitating baroreflex control in spontaneously hypertensive rats.
Why the study?
Does exercise improve autonomic and baroreflex control via nitric oxide modulation in spontaneously hypertensive rats?
Does exercise improve autonomic and baroreflex control via nitric oxide modulation in spontaneously hypertensive rats?
Answers are grounded in this paper and cite their sources.
Exercise improves cardiac autonomic and baroreflex control in hypertensive rats through the modulation of neuronal nitric oxide expression.
Nitric oxide (NO) is an intercellular signaling molecule that has association with cardiac autonomic function. The neuronal NO within the ventromedial and posterior periventricular (PVN) nuclei modulates the autonomic control of the circulation. study conducted by Raquel HA, et al. This strongly suggests that exercise augments autonomic control by augmenting PVN nNOS expression and the local generation of NO. ] Endogenous NO acting within the nucleus of the solitary tract (NTS) also facilitated baroreflex control by increasing the HR interval in which baroreceptors are able to correct pressure change in spontaneously hypertensive rats (SHR).
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Parasuraman Poovarasan (2020) conducted an editorial in Hypertension. Exercise was evaluated on Autonomic and baroreflex control. Exercise augments autonomic control by increasing PVN nNOS expression and local NO generation, facilitating baroreflex control in spontaneously hypertensive rats.
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