What question did this study set out to answer?

To investigate the etiology of recurrent fever, chills, and meningeal symptoms in a patient with systemic lupus erythematosus following ibuprofen exposure.

March 13, 1978JAMA

Ibuprofen-Induced Meningitis in Systemic Lupus Erythematosus

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Authors

HWHerbert L. Widener

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Implication

Case report reveals ibuprofen-induced meningitis in systemic lupus erythematosus, highlighting nonsteroidal anti-inflammatory drug neurotoxicity risks.

Key Points

To investigate the etiology of recurrent fever, chills, and meningeal symptoms in a patient with systemic lupus erythematosus following ibuprofen exposure.
Documented recurrent clinical episodes of fever, chills, and headache following ibuprofen ingestion in an individual with systemic lupus erythematosus (N=1).
Analyzed cerebrospinal fluid during a symptomatic episode to identify laboratory hallmarks of meningitis.
Performed a drug rechallenge under controlled conditions to determine causality.
Cerebrospinal fluid analysis demonstrated findings characteristic of acute meningitis following ibuprofen consumption.
Controlled drug rechallenge confirmed a direct causal relationship between ibuprofen ingestion and the onset of meningitis.

Cite This Study

Herbert L. Widener (1978) studied this question.

synapsesocial.com/papers/6a9e8cfee8f591a3e79bcd26 https://doi.org/10.1001/jama.1978.03280380062020

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Implication

Case report reveals ibuprofen-induced meningitis in systemic lupus erythematosus, highlighting nonsteroidal anti-inflammatory drug neurotoxicity risks.

Ibuprofen-Induced Meningitis in Systemic Lupus Erythematosus

Discussion

Member takes

Implication

Key Points

Cite This Study

Ibuprofen-Induced Meningitis in Systemic Lupus Erythematosus

Discussion

Member takes

Implication

Key Points

Cite This Study

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