Key result
S-nitrosothiols, formed by the reaction of nitric oxide with thiols, act as endothelium-dependent vasodilators, antithrombotic agents, and regulators of cardiac contractility.
This review examines the cardiovascular effects of S-nitrosothiols to better understand their role in physiologic and pathologic states.
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S-nitrosothiols may modulate vascular tone and thrombosis; leaves open therapeutic targeting pending prospective trials.
Nitric oxide (NO) is a simple heterodiatomic molecule with a broad range of biologic actions. In the cardiovascular system NO serves as an endothelium-dependent vasodilator, an antithrombotic agent, an antiproliferative molecule, and a regulator of cardiac contractility. Owing to its reactivity under physiologic conditions, accumulating data suggest that NO forms derivatives with several classes of biologic compounds. One group of biochemical functionalities that serves this role is that of thiols, which can form thionitrites or S-nitrosothiols with NO. In this paper we will examine the effects of the biologically known and the chemically produced S-nitrosothiols on the cardiovascular system in order to understand better what role these compounds may play in physiologic and pathologic states.
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Upchurch et al. (1996) conducted a review in Cardiovascular physiology and pathology. S-nitrosothiols was evaluated. S-nitrosothiols, formed by the reaction of nitric oxide with thiols, act as endothelium-dependent vasodilators, antithrombotic agents, and regulators of cardiac contractility.
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