Selective Synthesis of 2,3-Disubstituted-2H-isoindol-1-ylphosphonate and 2,3-Disubstituted-1,2-dihydroiso- quinolin-1-ylphosphonate via Metal-Tuned Reaction of α-Amino (2-Alkynylphenyl)methylphosphonate

Palladium(II)-catalyzed reaction of alpha-amino (2-alkynylphenyl)methylphosphonate provides a novel and efficient route to 2,3-disubstituted-2H-isoindol-1-ylphosphonate via 5-exo-cyclization and [1,5]-H shift; while 2,3-disubstituted-1,2-dihydroisoquinolin-1-ylphosphonate is afforded through 6-endo-cyclization utilizing silver triflate as catalyst.