The relationships between the multi-receptor binding profile of clozapine and olanzapine and their therapeutic properties were analyzed by using novel complexes built from the recently solved β2 adrenergic receptor structure. While interactions with position 3.36 determine the binding profile of clozapine-like ligands, diversity in TM5 and TM6 is responsible for subtle differences between clozapine and olanzapine.
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Selent et al. (2008) studied this question.
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