Infusion into the rat mesen-teric artery of tonin, an enzyme which forms angiotensin II directly from a natural protein plus the tetradecapeptide renin substrate, significantly potentiated the vasoconstrictor response to norepineph-rine. This effect was not inhibited by the simultaneous administration of an inhibitor of angiotensin I-converting enzyme or by SarAla8angiotensin II. These substances block the pressor effect of the angi-otensins I and II, respectively.
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Kondo et al. (1977) studied this question.