Heterocyclic compounds obtained by addition of acetylenedicarboxylic acid esters to thioureas, cyclic amidines and o‐difunctionalized aromatic systems have been studied by 13C‐NMR. In particular, C, H‐spin‐coupling constants over two and three bonds were used to differentiate between the various constitutional isomers and to establish the configuration of trisubstituted exocyclic C, C‐double bonds. The configurational significance and diagnostic value of vicinal cis and trans C,H‐spin coupling is again demonstrated in the present series.
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Vögeli et al. (1978) studied this question.
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