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The key to success in asymmetric Diels–Alder cycloadditions may be the preorganization of the reactants through combined covalent and coordinative bonds (dative OTi interactions). Even reactions with the difficult, monodentate, C2v-symmetric maleimide dienophiles give the desired adducts in high yields and respectable enantioselectivities [Eq. (a)]. R1 = H, CH3; R2 = CH3, PhCH2, p-BrC6H4CH2, (R)-PhCH2(CH3).
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Hugues Bienaymé (1997) studied this question.
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