Key result
High plasma endothelin-1 levels (≥1.71 pg/ml) in patients with essential hypertension were associated with a significantly higher frequency of carotid plaques (84% vs 62%) compared to normal levels.
Why the study?
Does high plasma endothelin-1 concentration correlate with the presence of carotid plaques in patients with essential hypertension?
Cross-Sectional (n=321)
No
Does high plasma endothelin-1 concentration correlate with the presence of carotid plaques in patients with essential hypertension?
High plasma endothelin-1 levels in patients with essential hypertension are associated with a higher frequency of non-calcified (soft) carotid plaques, suggesting a role in early atherosclerosis progression.
Answers are grounded in this paper and cite their sources.
No practice change from cross-sectional data; hypothesis-generating for endothelin-1 in hypertension-related atherosclerosis.
We studied the relationship between carotid plaques and plasma endothelin-1 concentration (ET-1) in patients with essential hypertension.A total of 212 patients (83 males, 129 females, 36-84 yr, mean age 63 yr) with essential hypertension (WHO stage I-II), and 109 age-matched control subjects (35-79 yr, mean 61 yr) were enrolled in this study. Plaque (defined as intima-media thickness 50% thicker than neibour intima-media thickness) in the both side of common carotid artery and the both side of internal carotid artery were measured by B-mode ultrasonography. Plaques were classified into soft plaque (without calcification) and hard plaque (with calcification) . ET-1 was measured by enzyme immunoassay.ET-1 levels were significantly higher in hypertensive patients than in control subjects. The frequency of plaque in patients with high ET-1 levels (ET-1≥1.71 pg/ml) was signficantly higher than those with normal ET-1 levels (ET-1<1.71 pg/ml) . The frequency of soft plaque in patients with high ET-1 levels was signficantly higher than those with normal ET-1 levels. But there was no difference between the frequency of hard plaque in patients with high ET-1 levels and that with normal ET-1 levels.These results indicate that high ET-1 levels with essential hypertension may play a role in the progression of carotid plaque without calcification.
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Minami et al. (1998) conducted a cross-sectional in Essential hypertension (n=321). High plasma endothelin-1 concentration (≥1.71 pg/ml) vs. Normal plasma endothelin-1 concentration (<1.71 pg/ml) was evaluated on Frequency of carotid plaque. High plasma endothelin-1 levels (≥1.71 pg/ml) in patients with essential hypertension were associated with a significantly higher frequency of carotid plaques (84% vs 62%) compared to normal levels.
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