A new cyclic heptapeptide cupolamide A ( 1 ) was isolated from two samples of the sponge Theonella cupola collected in Indonesia and Okinawa. It contains two l -Val, one d -Leu, and one d -Ser, and three uncommon amino acid residues, d -homoarginine (Har), trans -4-hydroxy- l -proline (Hyp), and l -2,4-diaminobutanoic acid (Dba). The structure elucidation of 1 was performed by NMR spectroscopic techniques and the stereochemistry was determined by Marfey's method. Cupolamide A ( 1 ) was active against P388 murine leukemia cells with an IC 50 = 7.5 μg/mL.
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Bonnington et al. (1997) studied this question.
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