Clomiphene Therapy in Hypogonadotrophism with Defective Olfaction

Letters and Comments1 October 1970Clomiphene Therapy in Hypogonadotrophism with Defective OlfactionHOMARD R. NANKIN, M.D., JAMES B. FIELD, M.D., PHILIP TROEN, M.D.HOMARD R. NANKIN, M.D.Search for more papers by this author, JAMES B. FIELD, M.D.Search for more papers by this author, PHILIP TROEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-4-660 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Clomiphene citrate administered to normal men for 6 days (50 mg every 6 hr) increases circulating luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (1). There was either no change or an inadequate increase in blood levels of gonadotropins when a 6-day course of clomiphene was given to men who had deficient olfactory acuity and hypogonadotrophic hypogonadism (1). Boyar (Ann Intern Med71:1127-1131, 1969) described an anosmic man with hypogonadotrophism who failed to respond to the standard 6-day test, but the continued administration of clomiphene (50 mg/day) for an additional 26 days was associated with an increase of...References1. BARDINROSSRIFKIND CGA: Studies of the pituitary-leydig cell axis in young men with hypogonadotrophic hypogonadism and hyposmia: comparison with normal men, prepuberal boys, and hypopituitary patients. J Clin Invest 48:2046, 1969 CrossrefMedlineGoogle Scholar2. NANKINDRASH HA: Unpublished observations. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of Pittsburgh School of Medicine Montefiore Hospital and Presbyterian-University Hospital Pittsburgh Pa. 15213 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFunctional MRI of Congenital Hyposmia: Brain Activation to Odors and Imagination of Odors and TastesFAMILIAL KALLMANN'S SYNDROME WITH AUTOSOMAL DOMINANT INHERITANCE, VARIABLE GONADOTROPIN DEFICIENCY AND SUBTLE COLOR VISION DEFECTSHypothalamic and pituitary function in hypogonadotropic hypogonadism8 Endocrine laboratory findings in pubertal disturbancesOlfactory Status and Response to Clomiphene in Male Gonadotrophin DeficiencyCARLOS R. HAMILTON JR., M.D., ROBERT I. HENKIN, M.D., GORDON WEIR, M.D., BERNARD KLIMAN, M.D.Delayed puberty, eroticism, and sense of smell: A psychological study of hypogonadotropinism, osmatic and anosmatic (Kallmann's syndrome) 1 October 1970Volume 73, Issue 4Page: 660-661KeywordsBloodFollicle stimulating hormoneFollicle-stimulating hormoneGonadotropinsHypogonadismLuteinizing hormone ePublished: 1 December 2008 Issue Published: 1 October 1970 PDF downloadLoading ...