Pharmacodynamics of Pulmonary Absorption in Man. I. Aerosol and Intratracheal Penicillin

Article1 October 1949PHARMACODYNAMICS OF PULMONARY ABSORPTION IN MAN. I. AEROSOL AND INTRATRACHEAL PENICILLINEDWARD A. GAENSLER, JOHN F. BEAKEY, MAURICE S. SEGAL, F.A.C.P.EDWARD A. GAENSLERSearch for more papers by this author, JOHN F. BEAKEYSearch for more papers by this author, MAURICE S. SEGAL, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-31-4-582 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDirect medication of the pulmonary epithelium is not a new development in therapeutics. It is readily understandable why interest in this accessible direct route of therapy should have developed during the early attempts to treat pulmonary disease. With the advent of successful specific oral and parenteral therapy, however, interest in primary medication of the lungs began to lag. The musculotropic and neurotropic action of bronchodilators, the belladonna group of alkaloids, and others, on the musculature and secretory cells of the bronchi was striking. Even more striking, however, was the immediate and prolonged relief afforded the asthmathic by the inhalation of...Bibliography1. GRAESERROWE JBAH: Inhalation of epinephrine for the relief of asthmatic symptoms, Jr. Allergy, 1935, vi, 415-420. CrossrefGoogle Scholar2. BRYSONSANSOMELASKIN VES: Aerosolization of penicillin solutions, Science, 1944, c, 33-35. CrossrefGoogle Scholar3. BARACHSILBERSTEINOPPENHEIMERHUNTERSOROKA ALFHETTM: Inhalation of penicillin aerosol in patients with bronchial asthma, chronic bronchitis, bronchiectasis and lung abscess: preliminary report, Ann. Int. Med., 1945, xxii, 485. Google Scholar4. SEGALRYDER MSCM: Penicillin aerosolization in the treatment of serious respiratory infections. A preliminary report, New England Jr. Med., 1945, ccxxxiii, 747. CrossrefGoogle Scholar5. 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Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication September 11, 1948.From the Department of Inhalational Therapy, Boston City Hospital, and the Department of Medicine, Tufts College Medical School. This study was aided by a grant from the Commercial Solvents Corporation. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAlternative Methods of Drug AdministrationPostoperative Pain Treatment by Means of a Morphine Aerosol: A Multicenter StudyEfficacy of absorption of sublingual and intravenous cardio-greenEndotracheal drug therapyA simple method for administering endotracheal medicationBlood levels of diazepam after endotracheal administration in dogsAuthor's replyLOCALIZED PULMONARY DISEASESBibliographyBronchiectasisAsthma bronchialeXIX Studies with Steam Generated Aerosols 1 October 1949Volume 31, Issue 4Page: 582-594KeywordsBronchiBronchodilatorsCellsEpitheliumHospital medicineInhalationLungsPenicillinPharmacodynamicsPulmonary diseases ePublished: 1 December 2008 Issue Published: 1 October 1949 PDF downloadLoading ...