Key result
The acute phase response inhibits reverse cholesterol transport and is associated with an increased risk of atherosclerosis in various inflammatory disorders.
The acute phase response, induced by various inflammatory conditions, is associated with an increased risk of atherosclerosis, potentially by inhibiting reverse cholesterol transport.
Associated with higher atherosclerosis risk in inflammation; leaves open whether targeting acute phase response improves outcomes.
The acute phase response (APR) is induced by infection, inflammation, trauma, and malignancy. The APR is characterized by alterations in hepatic protein synthesis leading to increases in specific plasma proteins, positive acute phase proteins, and decreases in other plasma proteins, negative acute phase proteins (1). Many disorders that induce the APR are associated with an increased risk of atherosclerosis (for example, rheumatoid arthritis, systemic lupus erythematosus, psoriasis, chronic dental infections, HIV infections).
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Feingold et al. (2010) conducted a review in Acute phase response and atherosclerosis. Acute phase response was evaluated. The acute phase response inhibits reverse cholesterol transport and is associated with an increased risk of atherosclerosis in various inflammatory disorders.
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