High‐resolution nuclear magnetic resonance has been used in order to investigate the base‐catalyzed reaction of formaldehyde with urea in deuterium oxide. We investigated the effects of temperature and concentration on the chemical shift of glycol species in formalin under basic condition. Assignment of all the signals appearing in the addition reaction was completed. The formation of N,N‐dimethylolurea, uron, monomethyloluron, and dimethyloluron was observed for the first time, as well as the formation of monomethylolurea, N,N′‐dimethylolurea, and trimethylolurea, which had been observed previously: the formation of presumptive tetramethylolurea could not be observed. The rate constants and equilibrium constant for urea, monomethylolurea, N,N′‐ and N,N‐dimethylolurea, and trimethylolurea were estimated by analysis of the decomposition reactions of monomethylolurea and N,N′‐dimethylolurea.
No takes yet. Share an insight, caveat, or question.
Tomita et al. (1976) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: