Enterogastrone Inhibits Eating by Fasted Mice

In mice fasted for 17 hours, administration of enterogastrone purified from hog duodenum reduced the food intake. This effect was greatest during the first 30 minutes, but the cumulative reduction continued for at least 4 hours. Other peptides prepared from hog duodenum or colon, as well as glucagon, secretin, glucose, and bovine serum albumin, were ineffective.