Key result
The mdx4cv mouse model of Duchenne cardiomyopathy exhibited significantly larger hearts and altered myocardial fiber orientation change in the right ventricle compared to normal controls.
Optical polarization tractography reveals significant structural remodeling and altered myocardial fiber organization, particularly in the right ventricle, in a mouse model of Duchenne cardiomyopathy.
Suggests right ventricular remodeling in Duchenne cardiomyopathy; leaves open translation to human disease and therapies.
We investigated the heart structural remodeling in the mdx4cv mouse model of Duchenne cardiomyopathy using optical polarization tractography. Whole heart tractography was obtained in freshly dissected hearts from six mdx4cv mice. Six hearts from C57BL/6J mice were also imaged as the normal control. The mdx4cv hearts were significantly larger than the control hearts and had significantly higher between-subject variations in myofiber organization. While both strains showed classic cross-helical fiber organization in the left ventricle, the rate of the myocardial fiber orientation change across the heart wall was significantly altered in the right ventricle of the mdx4cv heart.
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Wang et al. (2017) studied Duchenne cardiomyopathy (n=12). mdx4cv mouse model (Duchenne cardiomyopathy) vs. C57BL/6J mice (normal control) was evaluated on Heart structural remodeling (heart size, myofiber organization, rate of myocardial fiber orientation change). The mdx4cv mouse model of Duchenne cardiomyopathy exhibited significantly larger hearts and altered myocardial fiber orientation change in the right ventricle compared to normal controls.
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