Temperature Dependence of Electron Capture Detector Responses in the Analysis of Chlorpromazine, Diazepam, and Clonazepam

The temperature dependence of the responses of a pulsed 63 Ni electron capture detector to chlorpromazine, clomipramine, diazepam, flurazepam, and the N-ethyl derivatives of clonazepam and N-desmethylflunitrazepam were determined. The response to chlorpromazine and clomlpramine increases with temperature, while that to diazepam and flurazepom decreases with temperature. The response to N-ethylclonazepam and N-ethyldesmethylflunitrazepam exhibits very little temperature dependence. These results have been used to optimize the analysis of chlorpromazine, diazepam, and clonazepam in plasma by electron capture gas-liquid chromatography.