Inhibition of Lipid A Stimulated Activation of Human Dendritic Cells and Macrophages by Amino and Hydroxylamino Monosaccharides

Innovative mimics of lipid A were synthesized and shown to efficiently inhibit lipid A induced cytokine production in human dendritic cells and macrophages. These compounds, which consist of a D-glucose unit functionalized with an amine, ammonium, or hydroxylamine group and a five-membered ring at C6 (see structures) are promising leads for antisepsis-drug development owing to their lack of toxicity and their selectivity for the TLR4 receptor.