Key result
Gross total resection with mastoidectomy followed by proton beam therapy successfully treated a high-grade skull fibrosarcoma, with the patient remaining in good health at 8 years.
Why the study?
Adult type fibrosarcoma is rare and highly aggressive, and wide-margin surgical resection is difficult for skull lesions due to nearby critical organs.
Case Report (n=1)
Skull high-grade fibrosarcoma can be successfully managed with complete surgical resection combined with proton beam therapy.
Provides hypothesis-generating evidence for resection plus proton therapy in skull fibrosarcoma; prospective data needed before broader adoption.
Adult type fibrosarcoma is a rare and highly aggressive type of soft tissue tumor. Surgical resection with wide margins is the most effective, but difficult for the skull lesion as to the critical organ nearby. A 27-year-old Japanese woman presented a occipital tumor progressively enlarging for 2 months. CT scan showed an ovoid mass with osteolysis, extending to intracranially and subcutaneous tissue. MRI revealed the tumor involved transverse and sigmoid sinus. The gross total resection was achieved with mastoidectomy. The skull was reconstructed by titanium plate and bone cement. The proton beam irradiated after surgery. Chemotherapeutic agents were not administrated. Single lung metastasis was evident after 1 year later and removed. The patient is good in health at 8 years after initial diagnosis and got a baby. Skull high grade fibrosarcoma was successfully treated by entire surgical removal with proton beam therapy.
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Kitai et al. (2021) conducted a case report in Fibrosarcoma in the occipital bone (n=1). Gross total resection with mastoidectomy and proton beam therapy was evaluated on Patient health status and survival. Gross total resection with mastoidectomy followed by proton beam therapy successfully treated a high-grade skull fibrosarcoma, with the patient remaining in good health at 8 years.
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