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January 1, 2008HeterocyclesOpen Access

A Concise Approach to (±)-Tubifoline Based on the Palladium-Catalyzed Cross-Coupling Reaction of Indolylborate

Minoru Ishikura Norinobu Takahashi Koji Yamada Takumi Abe

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Abstract

The palladium-catalyzed tandem cyclization-cross-coupling protocol using 1H-indol-2-yltrialkylborate (indolylborate) proved to be a versatile approach to the generation of 2-(4-piperidylmethyl)indole, which was successfully used for the preparation of (±)-tubifoline.

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Ishikura et al. (2008) studied this question.

synapsesocial.com/papers/6a9ea036587425aad9aaf4a2 https://doi.org/10.3987/com-07-11190

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