Key result
A nonthrombogenic pulsatile left-heart bypass system provided better tissue perfusion and markedly reduced hemorrhage compared to nonpulsatile bypass techniques in animal experiments.
Why the study?
Does a nonthrombogenic pulsatile left-heart bypass system without anticoagulation improve tissue perfusion and reduce hemorrhage compared to nonpulsatile bypass techniques in animal models undergoing thoracic aorta cross-clamping?
Does a nonthrombogenic pulsatile left-heart bypass system without anticoagulation improve tissue perfusion and reduce hemorrhage compared to nonpulsatile bypass techniques in animal models undergoing thoracic aorta cross-clamping?
A nonthrombogenic pulsatile left-heart bypass system without anticoagulation improves hemodynamics and reduces hemorrhage in animal models, suggesting utility for prolonged thoracic aorta cross-clamping.
Does not support clinical use of pulsatile bypass; extends preclinical data but leaves human translation open.
A nonthrombogenic left-heart bypass system employing a pulsatile pump, porcine aortic valves, and polyurethan-polyvinyl-graphite-tetrahydrofuran-coated tubing to bypass the cross clamped thoracic aorta was evaluated in animal experiments. This system provided accurate control of proximal and distal aortic pressures and better tissue perfusion than nonpulsatile bypass techniques. Intraoperative and postoperative hemorrhage was markedly reduced because heparinization was not required. This nonthrombogenic pulsatile bypass would appear to be the method of choice to permit prolonged cross clamping of the thoracic aorta.
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Edward J. Serres (1970) studied cross clamped thoracic aorta. nonthrombogenic pulsatile left-heart bypass system vs. nonpulsatile bypass techniques was evaluated on tissue perfusion and hemorrhage. A nonthrombogenic pulsatile left-heart bypass system provided better tissue perfusion and markedly reduced hemorrhage compared to nonpulsatile bypass techniques in animal experiments.
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