February 20, 2020ACS Applied Bio Materials
MSC-Encapsulating in Situ Cross-Linkable Gelatin Hydrogels To Promote Myocardial Repair
Key result
MSC-encapsulating GH hydrogels significantly improved cardiac functional metrics (FS, EF, ESV) and reduced fibrosis in a mouse model of myocardial infarction.
Why the study?
Stem cell-based therapy for cardiac repair after myocardial infarction is limited in clinical translation by low retention and survival of transplanted cells.
Does MSC-encapsulating GH hydrogel improve cell retention and cardiac function in a mouse model of myocardial infarction?
Population
Mouse bone marrow-derived mesenchymal stem cells and infarcted hearts
Comparison
MSC-encapsulating GH hydrogels evaluated in vitro and in vivo
Design
Preclinical in vitro and in vivo study
Authors
Discussion
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Member takes
Implication
GH hydrogel may enhance stem cell retention post-MI; leaves open clinical translation of cardiac regeneration.
Structured PICO
Does MSC-encapsulating GH hydrogel improve cell retention and cardiac function in a mouse model of myocardial infarction?
P
Population
Mouse model of myocardial infarction (in vitro and in vivo)
I
Intervention
Gelatin-hydroxyphenyl propionic acid (GH) hydrogel encapsulating mouse bone marrow-derived mesenchymal stem cells (MSCs)
O
Outcome
Cell retention and survival, cardiac functional metrics (fractional shortening, ejection fraction, end-systolic volume), and cardiac structures (fibrosis, infarcted wall thickness)surrogate
GH hydrogels encapsulating MSCs improve cell retention, survival, and cardiac function in a preclinical model of myocardial infarction, offering a potential platform for cardiac tissue regeneration.
Cite This Study
Kim et al. (2020) studied Myocardial infarction. MSC-encapsulating gelatin-hydroxyphenyl propionic acid (GH) hydrogels was evaluated on Cardiac functional metrics (FS, EF, ESV) and cardiac structures. MSC-encapsulating GH hydrogels significantly improved cardiac functional metrics (FS, EF, ESV) and reduced fibrosis in a mouse model of myocardial infarction.