Abstract l-Hydroxyproline (1) and d-allo-hydroxyproline (2) were synthesized from d-glutamic acid (3) using the asymmetric center of 3 as that at C4 of 4-hydroxyproline. When the aqueous solution of 1 or 2 was heated at 200 °C for 2 hr, a solution in the equilibrium state, containing 55% of 1 and 45% of 2, was obtained. From this mixture, 1 was obtained by fractional crystallization.
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Eguchi et al. (1974) studied this question.
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