Key result
A nomogram incorporating age, ECOG, LDH, WCC, and Ki-67 index predicted overall survival in mantle cell lymphoma with a C-index of 0.81, significantly outperforming the IPI and MIPI scoring systems.
Why the study?
Does a nomogram incorporating clinicopathological parameters better predict overall survival in patients with mantle cell lymphoma compared to IPI and MIPI?
Cohort (n=281)
Yes
Does a nomogram incorporating clinicopathological parameters better predict overall survival in patients with mantle cell lymphoma compared to IPI and MIPI?
Absolute Event Rate: 0.81% vs 0.76%
p-value: p=<0.001
A novel nomogram incorporating clinicopathological parameters provides superior individual prediction of overall survival in mantle cell lymphoma compared to standard IPI and MIPI scoring systems.
Nomogram may refine MCL survival estimates; leaves open external validation before clinical use.
This study intended to present a practicable prognostic nomogram for patients with mantle cell lymphoma (MCL). The clinical data of 281 patients were reviewed. A nomogram that could predict overall survival (OS) was constructed based on the Cox proportional hazard model. To compare the capacity of the nomogram with the International Prognostic Index (IPI) and MCL International Prognostic Index (MIPI) scoring systems, we used the concordance index (C-index) to validate the veracity and the calibration curve. Age, Eastern Cooperation Oncology Group, lactate dehydrogenase, white cell count and Ki-67 were independent prognostic factors in the multivariate analysis and were subsequently included in the nomogram construction. The C-index was 0.81 and 0.79 in the primary and validation cohorts, respectively, which were superior to the predictive capacity of the IPI and MIPI systems in both cohorts. The nomogram makes it possible for physicians to predict patient OS individually and correctly, but certain limitations are noted.
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Zhu et al. (2018) conducted a cohort in Mantle cell lymphoma (n=281). Prognostic nomogram (age, ECOG, LDH, WCC, Ki-67) vs. IPI and MIPI scoring systems was evaluated on Overall survival prediction accuracy (C-index) (95% CI 0.78 to 0.84, p=<0.001). A nomogram incorporating age, ECOG, LDH, WCC, and Ki-67 index predicted overall survival in mantle cell lymphoma with a C-index of 0.81, significantly outperforming the IPI and MIPI scoring systems.
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