A number of anti-inflammatory agents were tested for their effect on the chemotaxis responsiveness and on the spontaneous motility of neutrophils obtained from rabbit and rat peritoneal exudates and human blood. The majority of these agents, both steroidal and nonsteroidal, inhibited the chemotactic responsiveness of neutrophils obtained from all three sources to a bacterial chemotactic factor. The effective steroidal anti-inflammatory agents tested inhibited both chemotaxis and spontaneous motility, whereas the nonsteroidal agents, with the exception of phenylbutazone, inhibited only chemotaxis and were without effect on motility.
No takes yet. Share an insight, caveat, or question.
Rivkin et al. (1976) studied this question.