Expressions suitable for the description of the behavior of small biological zwitterions in aqueous systems are developed. The validity and usefulness of the expressions are tested by correlating data for the activity coefficients of several amino acids in water. Development of rational expressions for the solid‐liquid equilibria (SLE) of amino acids, in terms of the heat of solution at infinite dilution, is also presented. The solubility data of phenylalanine, tyrosine and diiodotyrosine as a function of pH are successfully correlated using the approach developed here. In addition, simultaneous correlation of the pH and temperature dependence of solubility data for diodotyrosine in water gives very good representation. The expressions described here should prove useful for the design and optimization of separation processes, such as crystallization, with minimal experimental information.
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Kathryn K. Nass (1988) studied this question.
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