Author summary Four hundred and fifty patients with an open tibial fracture were randomized to receive either intramedullary nail fixation and routine soft-tissue management only, or with the addition of an implant containing either 0.75 mg / mL or 1.50 mg / mL of recombinant human bone morphogenetic protein-2 (rhBMP-2). In this study, the use of 1.50 mg / mL of rhBMP significantly reduced the number and invasiveness of secondary procedures, accelerated fracture and wound healing, and reduced the rates of infection, hardware failure, and overall pain.
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Govender et al. (2010) studied this question.
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