Groping in pockets. In order to evaluate the substrate specificity of the adenylation domain of the EA module of enniatin synthetase, a set of 30 α-D-hydroxy acid derivatives with various modifications in the side chain were synthesized and tested. Due to the low substrate specificity of enniatin synthetase a number of new unnatural enniatins could be synthesised (see scheme for example).
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Feifel et al. (2007) studied this question.
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