March 1, 1985Archives of Internal Medicine
Mitral Valve Prolapse in Sickle Cell Disease
Key result
Sickle cell disease was associated with a significantly higher prevalence of mitral valve prolapse compared to chronic anemia of end-stage renal disease (25% vs 3.0%).
Why the study?
Is the prevalence of mitral valve prolapse increased in patients with sickle cell disease compared to an anemic control group?
Population
92 patients, comprising 57 with sickle cell disease and 35 with chronic anemia of end-stage renal disease.
Comparison
M-mode echocardiography screening vs Anemic control group
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
No immediate change to MVP evaluation in sickle cell disease; leaves open a possible connective tissue link requiring prospective confirmation.
Study Design
Type
Cross-Sectional (n=92)
Structured PICO
Is the prevalence of mitral valve prolapse increased in patients with sickle cell disease compared to an anemic control group?
P
Population
92 patients, comprising 57 with sickle cell disease and 35 with chronic anemia of end-stage renal disease, evaluated for mitral valve prolapse.
E
Exposure
M-mode echocardiography screening
C
Comparator
Anemic control group (35 patients with chronic anemia of end-stage renal disease)
O
Outcome
Prevalence of mitral valve prolapse diagnosed by echocardiographysurrogate
Main Result
Absolute Event Rate: 25% vs 3%
Sickle cell disease is associated with a significantly higher prevalence of mitral valve prolapse compared to anemic controls, suggesting a possible linked connective tissue defect.
Cite This Study
Scott M. Lippman (1985) conducted a cross-sectional in Sickle cell disease (n=92). Sickle cell disease vs. Chronic anemia of end-stage renal disease was evaluated on Prevalence of mitral valve prolapse diagnosed by echocardiography. Sickle cell disease was associated with a significantly higher prevalence of mitral valve prolapse compared to chronic anemia of end-stage renal disease (25% vs 3.0%).