Key result
Denervation of chicken pectoralis muscle resulted in lower Ca2+-dependent ATPase activity and Ca2+ accumulation in the sarcoplasmic reticulum, suggesting a lower affinity for Ca2+.
Population
Adult chicken superior pectoralis muscle (fast-twitch skeletal muscle)
Comparison
Denervation vs Control (non-denervated muscle)
Design
Preclinical
Follow-up
20 days post-denervation
Authors
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Denervation alters avian fast-twitch SR Ca2+ handling; leaves open relevance to mammalian cardiac or skeletal muscle.
Denervation of fast-twitch skeletal muscle alters the sarcoplasmic reticulum by decreasing functional Ca2+ pump sites and lowering Ca2+ affinity.
Tate et al. (1983) studied Denervation of fast-twitch skeletal muscle. Denervation vs. Control (non-denervated muscle) was evaluated on Sarcoplasmic reticulum protein profile, Ca2+-dependent ATPase activity, and phosphoenzyme formation. Denervation of chicken pectoralis muscle resulted in lower Ca2+-dependent ATPase activity and Ca2+ accumulation in the sarcoplasmic reticulum, suggesting a lower affinity for Ca2+.
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