Key result
A comprehensive, customized, and cost-effective approach (CCCAP) targeting shared risk factors is proposed as an alternative strategy for the prevention of dementia, stroke, and heart disease.
Why the study?
Controversies and costs surrounding targeted Alzheimer treatments have highlighted the need to explore alternative approaches to dementia prevention, particularly understanding how some dementias are already being prevented in high-income countries.
Proposes a comprehensive, customized, and cost-effective approach to dementia prevention that integrates cardiovascular risk factor management.
Challenges aducanumab-centric strategies; leaves open whether comprehensive prevention explains declining dementia incidence in high-income countries.
The Food and Drug Administration's controversial approval of aducanumab has sounded a wake-up call. Is the search of a silver bullet to stop Alzheimer's disease the only way to prevent dementia? The controversies and costs have opened minds to alternative approaches, the most promising being that we are already preventing some dementias in some high-income countries but do not know yet how. This article proposes one way. It requires that the approach be (1) comprehensive, taking into account all relevant environmental, socioeconomic, and individual risk and protective factors; (2) customized, because contributing factors vary by region and among individuals; and (3) cost effective, implemented in actionable units. Savings of scale could occur by preventing stroke, heart disease, and dementia together. They share the same risk factors and pose risks for each other. Brain health could be the unifying, motivating, and actionable key to health, productivity, and well-being.
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Vladimir Hachinski (2022) conducted a review in Dementia. Comprehensive, customized, cost-effective approach (CCCAP) was evaluated. A comprehensive, customized, and cost-effective approach (CCCAP) targeting shared risk factors is proposed as an alternative strategy for the prevention of dementia, stroke, and heart disease.
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