[3H]Methcathinone (2-[3H]methylamino-1-phenylpropan-1-one), an inhibitor of monoamine reuptake transporters, was synthesized by N-methylation of cathinone using [3H]methyl iodide in toluene/ methanol. A two-step purification procedure employing preparative silica gel TLC, followed by reverse-phase HPLC, was developed to separate [3H]methcathinone from unreacted starting material and side products. We were able to generate radio- and chemically pure [3H]methcathinone, ready for use in pharmacological experiments, in about eight hours. Overall yield was about 4% based on [3H]methyl iodide.
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Cozzi et al. (1998) studied this question.