Key result
Direct infiltration of CaNa(3)DTPA into a 90Y-chloride contaminated puncture wound reduced radioactivity at the wound and in bone to 34.9% and 52.5% of controls, respectively.
Why the study?
Does local administration of CaNa(3)DTPA reduce 90Y distribution to bone more effectively than systemic administration in rats with 90Y-chloride contaminated puncture wounds?
Does local administration of CaNa(3)DTPA reduce 90Y distribution to bone more effectively than systemic administration in rats with 90Y-chloride contaminated puncture wounds?
Prompt local treatment with CaNa(3)DTPA is more effective than systemic treatment for removing 90Y from a contaminated puncture wound and minimizing its distribution to bone in a rat model.
Supports further investigation of local CaNa(3)DTPA for 90Y wounds; leaves open clinical translation.
The efficacy of diethylenetriaminepentaacetate calcium trisodium (CaNa(3)DTPA) in a dose of 34.7 micromol kg(-1) as a function of its route of administration was investigated in rats with a puncture wound contaminated by (90)Y-chloride at a concentration of 2.55 MBq kg(-1). Approximately 60% of (90)Y-chloride at a puncture wound was absorbed into the body of rats over 72 h post-puncture and radioactivity in femoral bone increased during the timed-release of (90)Y. Intravenous administration of CaNa(3)DTPA (systemic treatment) at 15 min post-puncture reduced (90)Y at a puncture wound and in bone up to 75.6 and 84.3% of controls, respectively. Direct infiltration of CaNa(3)DTPA into a puncture wound site (local treatment) at 15 min post-puncture diminished radioactivity at the puncture wound and in bone up to 34.9 and 52.5% of controls, respectively. Thus, prompt local treatment may be effective for removing (90)Y from a puncture wound and minimising (90)Y-distribution to bone compared with systemic treatment.
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Watanabe et al. (2005) studied Puncture wound contaminated by 90Y-chloride. CaNa(3)DTPA (diethylenetriaminepentaacetate calcium trisodium) vs. Controls was evaluated on Radioactivity at the puncture wound and in bone. Direct infiltration of CaNa(3)DTPA into a 90Y-chloride contaminated puncture wound reduced radioactivity at the wound and in bone to 34.9% and 52.5% of controls, respectively.
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