Aptamer and antibody functionalized Au nanoparticles are synthesized and used for protein detection (see figure). These particles are highly water soluble and as small as 10 nm. However, they are enlarged after a protein binding event to enhance signal sensitivity. A conventional western blot protocol is used to enable detection of the proteins with nanomolar sensitivity, with the naked eye.
No takes yet. Share an insight, caveat, or question.
Jana et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: