The palladium-mediated coupling of p-ethynylphenylalanine (p-epa) with hexabromobenzene afforded the benzene-bridged hexaalkynyl α-amino acid 1 in high yield. Deprotection of 1 at the carboxylate terminus yielded the free hexa acid which was treated with amine H2NC(CH2OCH2CH2CO2CH3)3 to give a hexapodal first-generation dendrimer.
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Kayser et al. (1999) studied this question.