Hot couplings without racemization: Protected peptides featuring C-terminal pseudoprolines were synthesized on a solid support, and these versatile building blocks were used in convergent peptide-segment couplings, which proceeded without racemization even under microwave conditions. The solubility-enhancing effect of pseudoproline residues facilitated the synthesis of complex RNase 39-mer glycopeptide thioesters.
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Heinlein et al. (2011) studied this question.
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