An Indian family with postaxial Polydactyly in four generations

An Indian family was observed with postaxial polycactyly in four generations. Of the twelve affected cases, eleven were male and one was female. The affected males showed postaxial polydactyly Type A in both hands and feet. The affected female showed polysyndactyly and both Types A and B postaxial polydactyly. Study of this family strongly suggests a common causal factor for postaxial polydactyly Types A and B and polysyndactyly. The observations also support an autosomal dominant pattern of inheritance and a high degree of genetic heterogeneity in ths malformation.