Using transmission electron microscopy, the intraepidermal free nerve endings in the back skin of spotted black and white guinea pigs were examined. Many intraepidermal free nerve endings were present in both the black areas and the white areas. They were located in the spaces between the basal lamina of the epidermis and the cytomembrane of the basal keratinocyte or in the intercellular spaces between the basal keratinocytes, but never beyond the Malphigian layers. Most of them appeared to belong to sensory nerves and some to adrenergic nerves. They seemed to be related intimately to epidermal keratinocytes.
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Mihara et al. (1982) studied this question.
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