Dextran-based polycations having different cation structures and contents were evaluated as carriers for transferring genes to mammalian cells in vitro. 2-(N,N-Dimethylamino)ethyl dextran having tertiary-amine-type cations induced very high transient gene expression in the COS-1 cells, while 2-aminoethyl dextran having primary-amine-type cations did not induced it at all. The cation content of the former was also found to affect the transient gene expression and the cytotoxicity of the polycations.
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Yamaoka et al. (1998) studied this question.
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