MoSe2-Au Based Sensitivity Enhanced Optical Fiber Surface Plasmon Resonance Biosensor for Detection of Goat-Anti-Rabbit IgG

Surface Plasmon resonance (SPR) provides an efficacious and label-free detection method for optical fiber bio-sensing. MoSe2is one of the transition metal dichalcogenides (TMDCs) which has broad applications in detecting specific reactions. Cysteamine hydrochloride with enriched groups can generate self-assemble films for tight attachment. In this study we aimed to combine the rapid response of optical fiber SPR sensors with the enhanced sensitivity of MoSe2nano-films. An optical fiber SPR biosensor with MoSe2-Au nanostructure was proposed and implemented, and a sensitivity of 2821.81 nm/RIU was achieved, which was approximately 98.7% higher than that of conventional SPR sensor without using MoSe2nanostructure. Furthermore, Bovine Serum Albumin (BSA) was utilized as the target molecule to test the bioaffinity of the biosensor with MoSe2deposition cycles from 0 to 8. Weighing the sensitivity and the figure of merit (FOM), the best deposition cycle of MoSe2was 4 with the sensitivity of 2793.36 nm/RIU and FOM of 37.24 RIU-1. At last, immunization experiments were carried out using Goat-anti-Rabbit IgG and a detection limit of 0.33 μg/mL was achieved. The rapid response and the high bioaffinity showed a strong applicability of the proposed MoSe2-Au SPR immune-sensor in specific interactions and immunization therapy.