Key result
Early development of phase 3 status, indicating effective control of the virus by CD8+ lymphocytes, correlated with a longer period of clinical normalcy in SIV-inoculated macaques.
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Should not yet influence HIV care; hypothesis-generating for CD8+ timing in SIV models.
We studied 15 macaques inoculated with SIV and identified three phases of infection. Phase 1 was characterized by activated lymphocytes in blood and infected cells in the CSF. In phase 2, activated cells were not detected but virus was recovered from mitogen-stimulated PBMC, while in phase 3, virus was recovered from mitogen-stimulated PBMC only after depletion of CD8+ lymphocytes, indicating effective control of the virus in peripheral blood. Early development of phase 3 status correlated with a longer period of clinical normalcy.
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Joag et al. (1994) studied SIV-induced disease (n=15). Early development of phase 3 status was evaluated on Period of clinical normalcy. Early development of phase 3 status, indicating effective control of the virus by CD8+ lymphocytes, correlated with a longer period of clinical normalcy in SIV-inoculated macaques.
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