Synthesis of 6- and 8-Phenyl-substituted Flavonoids

Abstract 3-Acetylbiphenyl-4-ol and -2-ol were condensed with substituted benzaldehydes to give respectively 5′-and 3′-phenyl-substituted chalcones (1a–k), which were cyclized to afford 6- and 8-phenylflavanones. The chalcones (1a–k) also gave the corresponding 6- and 8-phenylflavones via dibromides. The effects of the phenyl group on the spectral data are also discussed.