A murine bladder tumor model was evaluated for tumor growth retardation while receiving combination chemotherapy, either 40 mg/m2 methotrexate and 35 mg/m2 cis-platinum or 500 mg/m2 cytoxan and 35 mg/m2 cis-platinum at 3-week intervals. Tumor growth was observed in the control and treated groups. A significant decrease (p less than 0.001) in tumor growth and lung metastasis was noted in the cytoxan and cis-platinum group. Although the 40 mg/m2 group treated with methotrexate and 35 mg/m2 cis-platinum showed a decrease in tumor growth, it was not significant (p greater than 0.1), and lung metastasis was greater than in the control group. Cis-platinum with cytoxan was clearly effective in retarding tumor growth and metastatic spread.
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Murphy et al. (2009) studied this question.
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