Key result
Minimally invasive aortic valve replacement in octogenarians was associated with similar 5-year survival to conventional surgery (61.8% vs 47.0%, P=0.35) but reduced hospital stay and transfusions.
Why the study?
While percutaneous approaches are preferred in older adults, surgical outcomes are good and minimally invasive approaches may offer valuable advantages for octogenarians.
Does minimally invasive aortic valve replacement improve perioperative outcomes and survival compared to conventional aortic valve replacement in octogenarians?
Cohort (n=75)
Does minimally invasive aortic valve replacement improve perioperative outcomes and survival compared to conventional aortic valve replacement in octogenarians?
Minimally invasive aortic valve replacement in octogenarians improves perioperative recovery metrics, including shorter hospital stays and fewer transfusions, without compromising mid-term survival compared to conventional sternotomy.
Supports hypothesis of faster recovery with minimally invasive AVR in octogenarians; leaves open need for randomized trials to confirm survival equivalence.
Objective Aortic valve disease is more and more common in western countries. While percutaneous approaches should be preferred in older adults, previous reports have shown good outcomes after surgery. Moreover, advantages of minimally invasive approaches may be valuable for octogenarians. We sought to compare outcomes of conventional aortic valve replacement (CAVR) versus minimally invasive aortic valve replacement (MIAVR) in octogenarians. Methods We retrospectively collected data of 75 consecutive octogenarians who underwent primary, elective, isolated aortic valve surgery through conventional approach (41 patients, group CAVR) or partial upper sternotomy (34 patients, group MIAVR). Results Mean age was 81.9 ± 0.9 and 82.3 ± 1.1 years in CAVR and MIAVR patients, respectively ( P = 0.09). MIAVR patients had lower 24-hour chest drain output (353.4 ± 207.1 vs 501.7 ± 229.9 mL, P < 0.01), shorter mechanical ventilation (9.6 ± 2.4 vs 11.3 ± 2.3 hours, P < 0.01), lower need for blood transfusions (35.3% vs 63.4%, P = 0.02), and shorter hospital stay (6.8 ± 1.6 vs 8.3 ± 4.3 days, P < 0.01). Thirty-day mortality was zero in both groups. Survival at 1, 3, and 5 years was 89.9%, 80%, and 47%, respectively, in the CAVR group, and 93.2%, 82.4%, and 61.8% in the MIAVR group, with no statistically significant differences (log-rank test, P = 0.35). Conclusions Aortic valve surgery in older patients provided excellent results, as long as appropriate candidates were selected. MIAVR was associated with shorter mechanical ventilation, reduced blood transfusions, and reduced hospitalization length, without affecting perioperative complications or mid-term survival.
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Cammertoni et al. (2020) conducted a cohort in Aortic valve disease (n=75). Minimally invasive aortic valve replacement (MIAVR) vs. Conventional aortic valve replacement (CAVR) was evaluated on 5-year survival (p=0.35). Minimally invasive aortic valve replacement in octogenarians was associated with similar 5-year survival to conventional surgery (61.8% vs 47.0%, P=0.35) but reduced hospital stay and transfusions.
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