Key result
Among patients undergoing left atrial appendage occlusion, cirrhosis was associated with a higher 30-day readmission rate compared to those without cirrhosis (18.5% vs 9%; P=0.01).
Why the study?
Literature regarding outcomes associated with AF among cirrhosis patients who undergo LAAO device procedures is limited.
Does left atrial appendage occlusion in patients with cirrhosis compared to those without cirrhosis increase the risk of in-hospital adverse events and 30-day readmissions?
Cohort (n=54,897)
Yes
Does left atrial appendage occlusion in patients with cirrhosis compared to those without cirrhosis increase the risk of in-hospital adverse events and 30-day readmissions?
Absolute Event Rate: 18.5% vs 9%
p-value: p=0.01
LAAO in patients with cirrhosis is associated with similar in-hospital stroke and GI bleeding rates as those without cirrhosis, but carries a significantly higher risk of 30-day readmission.
May warrant closer post-LAAO monitoring in cirrhosis for readmissions; leaves open need for prospective trials on long-term safety.
AIMS: Literature regarding outcomes associated with atrial fibrillation among cirrhosis patients who had left atrial appendage occlusion (LAAO) device procedure is limited. We aim to evaluate the in-hospital clinical outcomes and 30-day readmissions among LAAO with and without cirrhosis. METHODS AND RESULTS: We performed a retrospective study of all hospitalizations associated with the LAAO procedure, using the Nationwide Readmissions Database for the years 2016-19. Primary outcomes were in-hospital clinical outcomes and 30-day readmissions. A total of 54 897 index hospitalizations for LAAO (female 41.8%) were reported. Of these, 905(1.65%) had cirrhosis. Gastrointestinal (GI) bleeding was reported in 44 (4.9%) vs. 1606 (2.97%) and coagulopathy in 21 (2.3%) vs. 521 (0.96%) in cirrhosis and without-cirrhosis groups, respectively. A total of 872 (1.59%) patients needed blood transfusion, 24 (2.7%) vs. 848(1.57%) in cirrhosis vs. without-cirrhosis groups (P = 0.047). Fresh frozen plasma (FFP) transfusion was reported among 888 (1.62%), with cirrhosis 26 (3%) vs. without cirrhosis 862 (1.6%) (P = 0.05). On adjusted multivariate logistic regression analysis, acute kidney injury, coagulopathy, FFP transfusion, and blood transfusion were strongly associated with cirrhosis, and GI bleeding, ischaemic stroke, and intracranial haemorrhage were not associated with cirrhosis. Readmissions in 30 days were 5028 (9.18%), 167 (18.5%) in the cirrhosis group and 4861 (9%) without-cirrhosis group (P = 0.01). On multivariate Cox regression, CHA2DS2-Vasc score of six was significantly associated with 30-day readmission compared with other scores [hazard ratio 2.24; 95% confidence interval (1.58-3.16); P < 0.001]. CONCLUSION: Left atrial appendage occlusion procedure in patients with cirrhosis had relatively similar GI bleeding and stroke rates, however, had higher rates of 30-day readmission. A higher CHA2DS2-Vasc score was more likely to be associated with 30-day readmissions and hence would help in discharge planning. The long-term safety and efficacy of LAAO in the cirrhosis population need to be demonstrated.
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Mir et al. (2023) conducted a cohort in Atrial fibrillation with and without cirrhosis (n=54,897). Cirrhosis vs. Without cirrhosis was evaluated on 30-day readmissions (p=0.01). Among patients undergoing left atrial appendage occlusion, cirrhosis was associated with a higher 30-day readmission rate compared to those without cirrhosis (18.5% vs 9%; P=0.01).