The effects of intravenous infusion of L‐tryptophan at doses of 75 and 100 mg/kg were compared with that of normal saline in healthy volunteers by means of a series of psychological and physiological measures. The 100 mg/kg infusion produced a 40 fold increase in free tryptophan and an 8 fold increase in the bound form. Few of the objective tests showed any differences. The electroencephalogram showed a significant increase in slow‐wave activity (4.0 to 7.5 Hz) and a trend toward decreased fast‐wave activity (13.5 to 26.0 Hz). Some impairment of a motor speed task was also noted. Reduction of arousal and increased drowsiness (but no euphoria) were shown by the subjective ratings.
No takes yet. Share an insight, caveat, or question.
Greenwood et al. (1974) studied this question.