Key result
In a descriptive study of 84 patients undergoing general anesthesia, propofol was the most commonly used induction agent (94.05%), while halothane was the most common maintenance agent (47.62%).
Why the study?
Drug utilization studies in general anesthesia help evaluate variation in drug selection and align prescribing patterns with standard guidelines to optimize drug therapy.
Observational (n=84)
No
This descriptive study highlights the prevalent use of propofol for induction and halothane for maintenance in general anesthesia at a tertiary hospital in India, emphasizing the need for pharmacoeconomic analysis.
Background:The drug utilization study in general anesthetics is useful in understanding and interpreting the wide variations of drug used, according to various surgical departments and helps to understand the preferences of drug used according to patient's profile and clinician choice and other related factors.So, by analyzing the decision of drug choice and comparing the prescribing pattern of health system with the existing standard guidelines, necessary changes can be made so that the drug therapy can be optimized. Aims/ objective:To study the drug utilization of patients undergoing general anesthesia with the objective of determining the percent utilization and dosing of various anesthetic agent and pre-anesthetic medication in tertiary care hospital of eastern India. Materials and Method:In this observational & prospective study, 84 patients undergoing surgery under general anesthesia with any ASA physical status were surveyed.Details of the pre-anesthetic medications and other medications prescribed were recorded.For the general anesthesia, the agent chosen for induction and maintenance were recorded along with the record of clinical status monitoring during anesthesia as well as recovery period and quality of recovery.Results: Glycopyrrolate and ondansetron were used in all patients whereas midazolam and fentanyl were used in more than 90% patients.Propofol was most commonly used inducing agent used in more than 95% cases.Halothane was used for maintenance of anesthesia in 47.92% of patients followed by isoflurane (41.67%).More than 95% of patients required skeletal muscle relaxant whereas more than 90% were given vecuronium.Most of the patients (66.67) were at level 2 of sedation as per Modified Ramsay Sedation Scale.75% of patients had Modified Aldrete Score of 9 while 25% had 10 score. Conclusion:The study results strongly suggest use of cheaper and cost-effective drugs.Thus, there is need for pharmacoeconomic analysis combined by pharmacovigilance activities to promote availability of newer drugs with better safety and efficacy.
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Singh et al. (2024) conducted an observational in Patients undergoing surgery under general anesthesia (n=84). General anesthesia medications was evaluated on Utilization rate of induction agents (Propofol). In a descriptive study of 84 patients undergoing general anesthesia, propofol was the most commonly used induction agent (94.05%), while halothane was the most common maintenance agent (47.62%).
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