Key result
A 21-year-old woman presenting with recurrent eosinophilic myocarditis developed dilated cardiomyopathy despite immunosuppressive treatment, leading to a genetic diagnosis of Danon disease.
Case Report (n=1)
Danon disease can present atypically as recurrent eosinophilic myocarditis, highlighting the importance of genetic testing in unexplained recurrent myocarditis progressing to dilated cardiomyopathy.
May prompt genetic testing for Danon disease in unexplained recurrent myocarditis; leaves open broader screening recommendations.
A 21-year-old woman with a history of atopy, peripheral eosinophilia, Wolf-Parkinson-White syndrome, and 5 episodes of myocarditis was diagnosed with eosinophilic myocarditis. Despite adequate immunosuppressive treatment and resolution of the myocarditis episode, the patient developed dilated cardiomyopathy and presented with worsening of her functional class. Finally, genetic testing unveiled an additional diagnosis: Danon disease. (Level of Difficulty: Advanced.)
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Angulo-Lara et al. (2023) conducted a case report in Danon disease and eosinophilic myocarditis (n=1). Immunosuppressive treatment was evaluated on Development of dilated cardiomyopathy and worsening functional class. A 21-year-old woman presenting with recurrent eosinophilic myocarditis developed dilated cardiomyopathy despite immunosuppressive treatment, leading to a genetic diagnosis of Danon disease.
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