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Summary The ability of B cell populations in the chicken to respond in vitro to LPS was evaluated. Chromosomally marked embryonic bursal cells were transferred to B cell depleted chicks and allowed to differentiate in vitro for several weeks. Subsequent evaluation of host and donor cell proliferation in LPS-stimulated spleen and peripheral blood lymphocyte cultures of cell recipients established that bursa-derived donor cells (B2 cells) in spleen and blood were capable of responding to LPS. The results furthermore suggested a weak response of host T cells to LPS. Lymphocytes within the bursa (B1 cells) failed to respond to this stimulant.
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W. Weber (1973) studied this question.
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