Vogt-Koyanagi-Harada Disease

Vogt-Koyanagi-Harada (VKH) disease, also known as uveomeningitic syndrome, is an idiopathic multisystem inflammatory disease with bilateral uveitis. Patients with bilateral anterior uveitis with vitiligo, poliosis, alopecia, and dysacousia were first described by Vogt in 1906 and then Koyanagi in 1929. Harada described a case of posterior uveitis with exudative retinal detachment and pleocytosis of cerebrospinal fluid (CSF), in 1926. Since these reports, it has become clear that these features are all contained within a single systemic inflammatory condition, which has become known as VKH disease.